Angiotensin Protocols

Donna Wang and a panel of hands-on experts describe in step-by-step detail all the major molecular, biochemical, and functional techniques now used in probing the renin-angiotensin system. These range from the use of embryonic gene targeting to create of mutant strains, to the functional investigation of components of the renin-angiotensin system. Comprehensive and highly practical, "Angiotensin Protocols" translates expert knowledge into readily reproducible methods that enable all biomedical investigators successfully to explore the role of angiotensin in health and disease today. "This is an advanced treatise on the renin-angiotensin system (RAS) and its regulation of the cardiovascular, renal, and neural relationships in health and disease. The introduction is ample to move the biological scientist reader up to adequacy to comprehend a complex patient example. ...The purpose shows a goal along with suitable objectives to move traditional medicine into utilization of the amazing explosion of modern biological techniques in RAS applications. It does so with a compilation of experts that foster a clearer picture of the modem RAS field. These are indeed worthy objectives, that surpass what individual papers and review articles can accomplish. Indeed it is needed and it serves as a tremendous thinking stimulator...The introduction by John E. Hall sets the tone and makes this book happen. The genetic manipulation of the RAS by Sigmund and Stec keeps the happening alive. the quantification of angiotensin II receptors by Wu, Yao and Wang is an outstanding peace of work. The cyclic AMP and GMP by Ji was helpful as was the NO from assay work of Thorup and Moore. The closing article on cerebral circulation by Lombard carries the exciting nature of the book to the interested student."-Doody's Health Sciences Book Review Journal "This book with great attention to the recent developments in molecular genetic, biochemical and fysiological techniques can be recommended to all researchers involved in the fundemental research of the RAS at the cellular level." - Acta Cardiologica